Agenda
Endgame 2026: global vision, local action
Day 1: defining the challenge
Arrival, registration, and coffee
Summit introduction and welcome
Session 1. The evolving global footprint of dengue: implications, challenges, and opportunities
Session objective: to discuss how the recent changes in global DENV distribution impacts traditional assumptions regarding risk and control
Coffee break
Session 2. Beyond the first week: understanding long-term sequalae and persistent public-health impacts of dengue
Session objective: to explore new observations of dengue’s long term impact on patients, communities, and how each are challenging traditional assumptions of factors driving risk and opportunities for control
Lunch Break (boxed lunch)
Session 3. Non-DENV flavivirus cross-talk: when/why does it matter?
Session objective: to review and discuss how and when non-DENV flavivirus immunity impacts DENV immunity and pathogenesis
Coffee break
Session 4. Genetics and dengue: virus, vector, and host
Session objective: to discuss and review what is known about virus, vector, and host genetics in regards to dengue transmission, immunity, and pathogenesis
Session 5. Latest-breaking science session
Session objective: late-breaking presentations selected from submitted poster abstracts
Closing remarks and group photo.
Happy hour, dinner, and poster session (Grand Hall)
Day 2, defining solutions
Arrival and coffee
Session 6. Countermeasure update: advanced clinical-stage interventions
Session objective: to review and discuss the state of advanced-stage dengue countermeasures. Presentations from advanced-stage countermeasure developers.
Coffee break
Session 7. Countermeasure update: preclinical interventions and models.
Session objective: to review and discuss the state of preclinical models of DENV infection and early-stage interventions.
Lunch break
Session 8. Advanced stage countermeasure update: vector control
Session objective: to review and discuss the state of advanced-stage dengue countermeasures. Presentations from advanced-stage countermeasure developers.
Coffee break (boxed lunch)
Session 9. Moving beyond antibodies: cellular and innate immunity in dengue
Session objective: to discuss the contribution of cellular and innate immunity in dengue immunity and pathogenesis
Closing remarks
Break
Session 10. Panel discussion: why do (some) people get (very) sick with dengue?
Session objective: to interactively discuss and debate current models of dengue immunity and pathogenesis, with a focus on how the evolution of these models may inform a dengue endgame
Social event (River Trail Beerworks)
Day 3, putting the pieces together
Arrival and coffee
Session 11. Panel discussion #2: regulatory challenges and opportunities in pursuit of a dengue endgame
Session objective: to discuss current regulatory challenges and opportunities that are either limiting or advancing progress towards a dengue endgame
Coffee break
Session 12. Cross-field fertilization: what can the dengue field learn from the successes and failures of other infectious disease control efforts?
Session objective: to discuss and review how the dengue field can learn from the successes and failures of other global infectious disease control efforts
Lunch Break (boxed lunch)
Session 13. The last mile: ensuring accurate science reaches those who need it most
Session objective: to discuss the role of science communication in global and local dengue control efforts
Coffee Break
Session 14. Local Interventions, Global Lessons: evidence-based approaches to dengue control
Session objective: to highlight, review, and discuss locally-tailored dengue control efforts and multi-level interventions
Session 15. Panel discussion #3: where do we go from here? Leadership and global coordination in pursuit of a dengue endgame
Session objective: to discuss the need for global coordination and leadership in pursuit of a dengue endgame
Closing remarks
Hotel Saranac – Saranac Lake, NY
and the
Trudeau Institute
