Agenda 2024

Endgame 2024: imagining a world with dengue control

Wednesday, August 7, 2024

Time	Session
8:00am – 8:45am	Arrival, registration, and coffee
8:45am – 9:00am	Welcome and introductions
9:00am – 10:00am	Session #1. Reality check: current state of dengue on the ground Objective: to discuss and review the current state of dengue around the world Jeremy Farrar, DPhil (WHO): “Welcome, and the current state of dengue” Laura Adams, DVM, MPH (CDC Dengue Branch): “Dengue in the United States”
10:00am – 10:20am	Coffee break
10:20am – 12:00pm	Session #2. Can we talk? Immunologic crosstalk between flaviviruses Objective: to review and discuss our current understanding of the impact of immunologic crosstalk between flaviviruses as it pertains to DENV pathogenesis and countermeasure efficacy Kathryn Anderson, MD PhD: “Deciphering the signal in the noise” Giovanna Barba Spaeth, PhD: “Flavivirus cross-talk: the impact of vaccination” Mattia Bonsignori, MD: “Functional B cell cross-reactivity profiling” Daniela Weiskopf, PhD: “Cross-reactivity between flavivirus specific T cells” Moderated discussion: Alan Rothman, MD
12:00pm – 1:00pm	Lunch Break (boxed lunch)
1:00pm – 1:40pm	Session #3. The changing face of dengue Objective: to discuss and review the shifting clinical burden of dengue Derek Cummings, PhD: “Shifting burdens of dengue across the globe” Eng Eong Ooi, MD PhD: “Dengue burden – new trends bring new uncertainties” Moderated discussion: Kathryn Anderson, MD PhD
1:40pm – 2:00pm	Coffee break
2:00pm – 3:20pm	Session #4. Signatures of DENV immunity & pathogenesis Objective: to discuss advances in our understanding of dengue pathogenesis Ernesto Marques, MD: “The complement system in dengue infection” Adam Waickman, PhD: “BCR-dependent enhancement of dengue virus infection” Taia Wang, MD PhD: “A fresh look at predicting dengue immunity” Moderated discussion: Ashley St. John, PhD
3:40pm – 4:20pm	Keynote presentation: Scott Halstead, MD “Dengue: confronting the pandemic”
4:20pm – 4:30pm	Closing remarks, day 1
4:30pm – 6:00pm	Happy hour and poster session (Grand Hall)

Thursday, August 8, 2024

Time	Session
8:00am – 8:30am	Arrival and coffee
8:30am – 8:40am	Welcome and recap of Day 1
8:40am – 10:20am	Session #5. Advances in preclinical & clinical models Kirk Prutzman, PhD: “Regulatory considerations for dengue vaccine evaluation” Alan Barrett, PhD: “Preclinical animal models for dengue countermeasures” Stephen Thomas, MD: “Lessons from the Dengue Human Infection Model Consortium” Beth Kirkpatrick, MD: “Human challenge models for vaccine evaluation” Moderated discussion: Nelson Michael, MD PhD
10:20am – 10:40am	Coffee break
10:40am – 12:00pm	Session #6. Advances in dengue diagnostics Frank Middleton, PhD: “Saliva-Based Nucleic Acid Detection” Priscila Da Silva Castanha, PhD: “Discovery of Biomarkers” Marco Hamins-Puertolas, PhD: “Leveraging serological data” Moderated discussion: Alan Landay, PhD
12:00pm – 1:00pm	Lunch Break (boxed lunch)
1:00pm – 2:20pm	Session #7. Vectors, vector control, and interventions Rebecca Christofferson, PhD: “Historical challenges and solutions” George Dimopoulos, PhD: “Exploiting Aedes-arbovirus interactions” Fabiano Oliverira, MD PhD: “Antibodies to Aedes aegypti” Moderated discussion: Saravanan Thangamani, PhD
2:20pm – 2:40pm	Coffee break
2:40pm – 3:40pm	Session #8. Next-generation countermeasures Lillian Chiang: “Human sirtuin 2 protein” Phil Santangelo, PhD: “mRNA-encoded Cas13” Moderated discussion: Aaron Farmer, DO
4:00pm – 5:00pm	Session #9. Advanced countermeasure update Shibadas Biswal, MBBS: “Takeda’s dengue vaccine rollout” Bhagwat Gunale, MD: “Phase 2 clinical trial of Dengue monoclonal antibody” Guillermo Herrera-Taracena, MD: “Insights from Phase 2 Dengue Prophylactic study” Moderator: Albert Ko, MD
5:00pm – 6:00pm	Closing remarks, day 2

Friday, August 9, 2024

Time	Session
8:00am – 8:30am	Arrival and coffee
8:30am – 8:40am	Welcome and recap of Day 2
8:40am – 9:40am	Session #11. Reading between the lines Alex Perkins, PhD: “Coordinated deployment of approaches” Ilaria Dorigatti, PhD: “Modelling dengue interventions” Moderated discussion: Michael Johansson, PhD
10:00am – 11:20am	Session #12. Vaccines alone don’t save lives Telisa Stewart, MPH DrPH: “Vaccination Playbook” Jana Shaw, MD: “Strategies to Combat Vaccine Hesitancy” Hoe Nam Leong, MD: “Dengue Vaccines – Asian Perspectives” Moderated discussion: Rebecca Christofferson, PhD
11:20am – 11:30am	Closing remarks